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Literature summary extracted from
- Bovine Hageman factor and its fragments (1988), Methods Enzymol., 163, 54-68.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.38 | plasma kallikrein | factor XII is activated by plasma kallikrein in the presence of kaolin and high molecular weight kininogen stimulates the activation 4fold to 5fold. Factor XII is also activated by plasma kallikrein in the presence of vesicles of acidic lipids, such as sulfatides, ganglioside, stearic acid, and cholesterol sulfate | Bos taurus |
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.4.21.38 | synthesis | the enzyme is used for preparation of factor Xia and plasma kallikrein | Bos taurus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.38 | Bos taurus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.21.38 | - |
Bos taurus |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.38 | additional information | - |
- |
Bos taurus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.38 | factor VII + H2O | bovine factor VII, a single Arg-Ile bond in factor VII is cleaved and the single chain form of factor VII is converted into a two-chain molecule | Bos taurus | factor VIIa | - |
? |  |
| 3.4.21.38 | factor XI + H2O | - |
Bos taurus | factor XIa + ? | - |
? | |
| 3.4.21.38 | prekallikrein + H2O | - |
Bos taurus | ? | - |
? | |
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